14:[["$","title","0",{"children":"流程图 TD\n A[开始：营养过剩/肥胖] --> B[脂肪组织病理性扩张
细胞肥大，缺氧，应激]\n ... | SciDraw Gallery"}],["$","meta","1",{"name":"description","content":"流程图 TD\n A[开始：营养过剩/肥胖] --> B[脂肪组织病理性扩张
细胞肥大，缺氧，应激]\n \n B --> C[局部炎症和功能障碍
巨噬细胞浸润 M1极化
脂联素↓ 促炎因子↑]\n \n C --> D{全身信号输出}\n \n D --> E[异常分泌谱
(脂肪因子，细胞因子)]\n D --> F[脂毒性物质溢出
(FFA，神经酰胺)]\n D --> G[外泌体介导的通讯
(携带特定miRNA等)]\n \n E & F & G --> H[靶器官损伤和功能障碍]\n \n subgraph H [靶器官损伤和功能障碍]\n H1[肝脏：胰岛素抵抗，
糖异生↑，脂质沉积]\n H2[骨骼肌：胰岛素抵抗，
葡萄糖摄取↓]\n H3[胰腺β细胞：功能障碍，
炎症，凋亡]\n H4[下丘脑：中枢抵抗，
食欲调节失衡]\n end\n \n H --> I[全身胰岛素抵抗
+ β细胞衰竭]\n I --> J[最终结果：2型糖尿病 T2DM]\n \n K[外部调节因素
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细胞肥大，缺氧，应激]\n ... | SciDraw Gallery"}],["$","meta","17",{"property":"og:description","content":"流程图 TD\n A[开始：营养过剩/肥胖] --> B[脂肪组织病理性扩张
细胞肥大，缺氧，应激]\n \n B --> C[局部炎症和功能障碍
巨噬细胞浸润 M1极化
脂联素↓ 促炎因子↑]\n \n C --> D{全身信号输出}\n \n D --> E[异常分泌谱
(脂肪因子，细胞因子)]\n D --> F[脂毒性物质溢出
(FFA，神经酰胺)]\n D --> G[外泌体介导的通讯
(携带特定miRNA等)]\n \n E & F & G --> H[靶器官损伤和功能障碍]\n \n subgraph H [靶器官损伤和功能障碍]\n H1[肝脏：胰岛素抵抗，
糖异生↑，脂质沉积]\n H2[骨骼肌：胰岛素抵抗，
葡萄糖摄取↓]\n H3[胰腺β细胞：功能障碍，
炎症，凋亡]\n H4[下丘脑：中枢抵抗，
食欲调节失衡]\n end\n \n H --> I[全身胰岛素抵抗
+ β细胞衰竭]\n I --> J[最终结果：2型糖尿病 T2DM]\n \n K[外部调节因素
(肠道菌群失调/益生菌干预)] -.->|双向影响| B\n K -.->|双向影响| C\n \n L[新兴治疗靶点和策略] -.->|干预| C\n L -.->|干预| E\n L -.->|干预| F\n L -.->|干预| G"}],["$","meta","18",{"property":"og:url","content":"https://sci-draw.com/zh/gallery/gal_1769504532927_8tzv5ly"}],"$L23","$L24","$L25","$L26","$L27","$L28","$L29","$L2a","$L2b","$L2c","$L2d","$L2e","$L2f"]