提示詞描述

ABSTRACT MICROCHIPS ARE USEFUL IN CLINICAL THERAPY, DISEASE DIAGNOSIS, AND ENVIRONMENTAL MONITORING. MANY MICROCHIPS OFFER GREAT SENSITIVITY, SPECIFICITY, QUICK RESPONSE TIMES, AND EASE OF USE. AMONG THESE, MICROCHIPS THAT UTILIZE MICRO-NANOSTRUCTURE PARTICLES WILL INEVITABLY PLAY A VITAL ROLE IN FUTURE PROGRESS. HOWEVER, ENERGY-EFFICIENT AND DIRECTIONALLY GUIDED FLUID TRANSPORT ON MICROCHIPS REMAINS A MAJOR CHALLENGE IN DIAGNOSTIC METHODS. THIS RESEARCH PROPOSES TO DEVELOP NANOMATERIAL-BASED SUPERWETTABLE AND SLIPPERY MICROCHIPS USING CANDLE-SOOT-DERIVED SILICA NANOSTRUCTURES, PHOTOLITHOGRAPHY-ASSISTED HYDROPHILIC PATTERNS, AND RGD-PEPTIDE BIOFUNCTIONALIZATION. SLIPPERY LIQUID INFUSED SUPERHYDROPHOBIC ZONES WILL BE CREATED USING PERFLUORINATED POLYETHER (PFPE) TO ACHIEVE ANTIFOULING, ANALYTE ENRICHMENT, AND ENERGY-FREE DROPLET TRANSPORT. THE HYDROPHILIC ZONES WILL BE FUNCTIONALIZED WITH ARG-GLY-ASP (RGD) PEPTIDES TO PROVIDE BIOLOGICALLY ACTIVE AND HEMOCOMPATIBLE CAPTURE INTERFACES FOR HIGHLY SENSITIVE DETECTION OF PROSTATE-SPECIFIC ANTIGEN (PSA).