14:[["$","title","0",{"children":"フローチャート TD\n A[開始: 過栄養/肥満] --> B[脂肪組織の病的な拡大
細胞肥大、低酸素... | SciDraw Gallery"}],["$","meta","1",{"name":"description","content":"フローチャート TD\n A[開始: 過栄養/肥満] --> B[脂肪組織の病的な拡大
細胞肥大、低酸素、ストレス]\n \n B --> C[局所的な炎症と機能不全
マクロファージ浸潤 M1 極性化
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細胞肥大、低酸素... | SciDraw Gallery"}],["$","meta","17",{"property":"og:description","content":"フローチャート TD\n A[開始: 過栄養/肥満] --> B[脂肪組織の病的な拡大
細胞肥大、低酸素、ストレス]\n \n B --> C[局所的な炎症と機能不全
マクロファージ浸潤 M1 極性化
アディポネクチン↓ 炎症性因子↑]\n \n C --> D{全身性シグナル出力}\n \n D --> E[異常な分泌プロファイル
(アディポカイン、サイトカイン)]\n D --> F[リポ毒性物質の流出
(遊離脂肪酸、セラミド)]\n D --> G[エクソソームを介したコミュニケーション
(特定の miRNA などを運搬)]\n \n E & F & G --> H[標的臓器の損傷と機能不全]\n \n subgraph H [標的臓器の損傷と機能不全]\n H1[肝臓: インスリン抵抗性、
糖新生↑、脂質沈着]\n H2[骨格筋: インスリン抵抗性、
グルコース取り込み↓]\n H3[膵臓β細胞: 機能不全、
炎症、アポトーシス]\n H4[視床下部: 中枢性抵抗性、
食欲調節の不均衡]\n end\n \n H --> I[全身性インスリン抵抗性
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(腸内細菌叢のディスバイオシス/プロバイオティクス介入)] -.->|双方向の影響| B\n K -.->|双方向の影響| C\n \n L[新たな治療標的と戦略] -.->|介入| C\n L -.->|介入| E\n L -.->|介入| F\n L -.->|介入| G"}],"$L23","$L24","$L25","$L26","$L27","$L28","$L29","$L2a","$L2b","$L2c","$L2d","$L2e","$L2f","$L30"]