{"@context":"https://schema.org","@type":"ImageObject","name":"Flowchart TD\n A[Start: Overnutrition/Obesity] --> B[Pathological Expansion of Adipose Tissue
C","description":"Flowchart TD\n A[Start: Overnutrition/Obesity] --> B[Pathological Expansion of Adipose Tissue
Cell Hypertrophy, Hypoxia, Stress]\n \n B --> C[Local Inflammation and Dysfunction
Macrophage Infiltration M1 Polarization
Adiponectin↓ Pro-inflammatory Factors↑]\n \n C --> D{Systemic Signal Output}\n \n D --> E[Abnormal Secretory Profile
(Adipokines, Cytokines)]\n D --> F[Spillover of Lipotoxic Substances
(FFA, Ceramides)]\n D --> G[Exosome-Mediated Communication
(Carrying Specific miRNAs, etc.)]\n \n E & F & G --> H[Target Organ Damage and Dysfunction]\n \n subgraph H [Target Organ Damage and Dysfunction]\n H1[Liver: Insulin Resistance,
Gluconeogenesis↑, Lipid Deposition]\n H2[Skeletal Muscle: Insulin Resistance,
Glucose Uptake↓]\n H3[Pancreatic β-cells: Dysfunction,
Inflammation, Apoptosis]\n H4[Hypothalamus: Central Resistance,
Appetite Regulation Imbalance]\n end\n \n H --> I[Systemic Insulin Resistance
+ β-cell Failure]\n I --> J[Final Outcome: Type 2 Diabetes T2DM]\n \n K[External Regulatory Factors
(Gut Microbiota Dysbiosis/Probiotic Intervention)] -.->|Bidirectional Influence| B\n K -.->|Bidirectional Influence| C\n \n L[Emerging Therapeutic Targets and Strategies] -.->|Intervention| C\n L -.->|Intervention| E\n L -.->|Intervention| F\n L -.->|Intervention| G","contentUrl":"https://pub-8c0ddfa5c0454d40822bc9944fe6f303.r2.dev/ai-drawings/VUg3JkBRW1uQc1pqblFstheZ9YfuVku7/a1920a1e-9109-4fc8-b081-9df972c6a837/c6a26c86-53fc-4513-99bf-7e30a9321610.png","thumbnailUrl":"https://pub-8c0ddfa5c0454d40822bc9944fe6f303.r2.dev/ai-drawings/VUg3JkBRW1uQc1pqblFstheZ9YfuVku7/a1920a1e-9109-4fc8-b081-9df972c6a837/c6a26c86-53fc-4513-99bf-7e30a9321610.png","url":"https://sci-draw.com/en/gallery/gal_1769504532927_8tzv5ly","datePublished":"2026-01-27T09:02:12.928Z","author":{"@type":"Organization","name":"SciDraw","url":"https://sci-draw.com"},"publisher":{"@type":"Organization","name":"SciDraw","url":"https://sci-draw.com","logo":{"@type":"ImageObject","url":"https://sci-draw.com/logo.png"}},"isPartOf":{"@type":"ImageGallery","name":"AI Scientific Illustration Gallery","url":"https://sci-draw.com/en/gallery"}}