Prompt Description

Background: The estimated Glucose Disposition Ratio (eGDR) has been associated with stroke. However, its specific role in predicting stroke incidents within the Circran Syndrome (CircS) population remains underexplored. Methods: A prospective cohort study was conducted involving 3,128 patients with CircS from the China Health and Retirement Longitudinal Study (CHARLS). The primary outcome was the incidence of stroke during follow-up. Cox proportional hazards models, Kaplan-Meier (KM) analysis, restricted cubic spline (RCS) analysis, subgroup analysis, and area under the curve (AUC) analysis were performed. Results: Over a median follow-up of 108 months, 409 (13.07%) stroke incidents were recorded. After full adjustment, each unit increase in eGDR was associated with a 10% reduction in stroke risk (HR=0.90, 95% CI: 0.84-0.96, p=0.002). A significant inverse dose-response relationship was observed across eGDR quartiles (P for trend <0.001), with the highest quartile showing a 46% lower risk (HR=0.54, 95% CI: 0.3