Prompt Description

APPROVED. Graphical abstract design for Advanced Science journal: Panel 1 (Injury): Depict a brain with striatal hemorrhage, highlighting a red hematoma and a ruptured blood vessel icon. Label: 'Intracerebral Hemorrhage (ICH)'. Panel 2 (Circadian disruption): Illustrate the hypothalamus with a prominent, malfunctioning clock (misaligned/broken hands). Include a sun/moon icon to represent a disrupted sleep-wake cycle. Text: 'Circadian disruption ↓ Clock gene regulation'. Panel 3 (Exacerbated brain injury): Vertical split. Top (WT + ICH): Show moderate immune cell activity (microglia/astrocytes), an intact blood-brain barrier (BBB), and moderate neuronal loss. Label: 'Controlled injury response'. Bottom (Clock−/− + ICH): Show strong immune cell infiltration, a compromised/leaky BBB, and neuronal apoptosis. Label: 'Exaggerated secondary injury'. Overall: A single arrow spanning all panels, labeled: 'Circadian dysregulation exacerbates ICH outcome'.