Prompt Description

Create a mechanistic illustration depicting the contribution of trace metal imbalance and genetic susceptibility to prostate carcinogenesis, emphasizing biological interpretation rather than study design or methodologies. The figure should employ a soft, desaturated color palette dominated by sage green, muted teal, pale olive, and warm beige/ochre accents, avoiding bright or saturated colors. Position a prostate epithelial cell at the center of the illustration. Illustrate trace metal imbalances, specifically elevated cobalt (Co), nickel (Ni), copper (Cu), and molybdenum (Mo), alongside reduced zinc (Zn), to represent an altered intracellular metal environment. Represent these metals as subtle icons influencing cellular homeostasis. Depict increased reactive oxygen species (ROS) production, oxidative stress, mitochondrial dysfunction, and DNA damage resulting from excess pro-oxidant metals. Use soft ochre/amber tones to represent ROS, avoiding red hues. Illustrate key antioxidant pathways involving thioredoxin reductase 2 (TXNRD2), glutathione peroxidase 6 (GPX6), and nuclear factor erythroid 2-related factor 2 (NFE2L2/NRF2). Depict how genetic variability may influence these pathways.