Prompt Description

Schematic representation of four key genes involved in detoxification and oxidative stress pathways associated with prostate cancer susceptibility. The figure highlights TXNRD2 as the main candidate gene, involved in mitochondrial redox homeostasis and oxidative damage control, showing evidence of association in an independent replication cohort. NFE2L2 (NRF2) is depicted as the master regulator of the antioxidant response; reduced expression in prostate tumor tissue leads to impaired activation of cytoprotective genes. ARNT is shown as a transcriptional cofactor in xenobiotic detoxification and hypoxia-related pathways, potentially affecting angiogenesis and metabolic reprogramming in prostate cancer. GPX6 is included as a selenoprotein involved in peroxide detoxification and redox signaling, with a more exploratory role in prostate cancer. Overall, the figure illustrates the convergence of these genes on oxidative stress control and detoxification processes relevant to prostate cancer.