Prompt Description

Graphical abstract to improve diagnosis and risk stratification in familial prostate cancer through the integration of genomic, epigenomic, and clinical data. In the left panel, show families with prostate cancer aggregation (pedigree), highlighting affected individuals. From these individuals, represent the collection of blood samples for germline DNA extraction. Controls are from a database. In the center, illustrate whole-genome sequencing using Oxford Nanopore technology, emphasizing that two layers of information are simultaneously obtained from the same DNA molecule: (1) genetic variation (SNVs, indels, and structural variants) and (2) DNA methylation (CpG sites and regulatory regions). Next, show two parallel analysis streams: one genomic and one epigenomic, which converge in a multi-omic integration block. In this block, represent the identification of functional relationships in...