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Event timeline extraction based on electronic medical rec... | SciDraw Gallery

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Event timeline extraction based on electronic medical records.

Biomedical

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Event timeline extraction based on electronic medical records.

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Schematic diagram illustrating the principle of a senescence detection fluorescent probe based on β-Gal enzyme activation, showing the process from fluorescence quenching to activation.

Schematic diagram illustrating the principle of a senescence...

I want to create a graphical abstract for an article, requiring an editable vector image with English text. The research focuses on using the Chinese herb Ophiopogon japonicus (OJ) to treat Parkinson's disease, comparing OJ from two different origins and extracts prepared using different extraction methods. The samples used for animal experiments were: Sichuan OJ water extract (COJ-W), Sichuan OJ ethanol extract (COJ-E), Zhejiang OJ water extract (ZOJ-W), and Zhejiang OJ ethanol extract (ZOJ-E). These four extracts were administered to mice via gavage for 28 days. Two days after the start of administration, a mouse PD model was established by intraperitoneal injection of MPTP. Subsequently, behavioral tests such as the Pole test, rotarod test, gait analysis, Morris water maze, and open field test were performed to demonstrate efficacy. Fluorescent staining of TH+ cells was performed on mouse brain sections, followed by WB detection of TH+ and α-synuclein proteins in the midbrain. The levels of inflammatory cytokines IL-6, IL-1β, TNF-α, and IFN-γ in brain tissue were measured. We also performed 16s rRNA sequencing on the feces of mice to investigate changes in the gut microbiota. The safety of the four extracts in mice was also evaluated. The results showed that OJ extracts had effects on the indicators measured by the above methods. The summary of the results is as follows: OJ extracts significantly ameliorated MPTP-induced motor deficits, anxiety-like behaviors, and cognitive impairments in mice, with the water extract from Sichuan OJ demonstrating superior efficacy. OJ also improved the number of TH⁺ neurons, upregulated TH⁺ protein expression and downregulated α-synuclein expression in the brain. Furthermore, OJ reduced the levels of pro-inflammatory cytokines IL-6, IL-1β, TNF-α, and IFN-γ in the brain. Gut microbiota analysis revealed that OJ extracts markedly modulate the gut microbiota.

I want to create a graphical abstract for an article, requir...

The tumor microenvironment (TME) is a heterogeneous environment encompassing cancer cells, blood vessels, infiltrating immune cells, resident stromal cells, fibroblasts, signaling molecules, and the extracellular matrix (PMID 24310355; PMID 25838376; PMID 26938687; PMID 21963199; Anderson, N. M., & Simon, M. C. (2020). The tumor microenvironment. Current Biology: CB, 30(16), R921–R925. https://doi.org/10.1016/j.cub.2020.06.081; Hanahan, D., & Weinberg, R. A. (2000). The Hallmarks of Cancer. Cell, 100(1), 57–70. https://doi.org/10.1016/S0092-8674(00)81683-9). The TME is dynamic, and its composition varies depending on the cancer type and stage. In cancerous tissue, insufficient perfusion (limited oxygen delivery and decreased removal of acidic waste (PMID: 29891961)), combined with altered energy metabolism and uncontrolled proliferation, leads to an overall acidic TME (PMID: 2684393; PMID: 22360557).

The tumor microenvironment (TME) is a heterogeneous environm...

A representative figure illustrates crowding zones in the upper, lower, right, and left visual fields. Fixation is plotted at the center. Concentric circles represent different eccentricities (4, 8, 12, 16), and representative crowding zones are plotted on these circles. Crowding zones are larger in the radial direction than in the tangential direction, smaller in the left and right visual fields than in the lower and upper visual fields, and larger at higher eccentricities than at closer eccentricities. A similar figure was presented in Greenwood et al. 2017 PNAS paper, Figure 2a.

A representative figure illustrates crowding zones in the up...