
Weight-Adjusted Waist Index and Risk of Cardiovascular and All-Cause Mortality in Chronic Kidney Disease: NHANES 2005–2018 Analysis Abstract. Chronic kidney disease (CKD) represents a significant global health challenge with strong associations to cardiovascular mortality. Conventional obesity indices, such as body mass index (BMI) and waist circumference (WC), may not fully reflect adiposity-related risk in CKD. The weight-adjusted waist index (WWI) is a relatively new anthropometric measure, and its prognostic utility in CKD remains to be fully elucidated. This study aims to investigate the relationship between the weight-adjusted waist index (WWI) and mortality outcomes, specifically CVD-specific and all-cause mortality, in individuals with CKD. This retrospective cohort study utilized data from the National Health and Nutrition Examination Survey (NHANES 2005–2018) and the National Death Index (NDI). Over a median follow-up period of 79 months involving 5,381 participants, higher WWI quartiles were associated with progressively increased risks of cardiovascular disease.
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