Prompt Description

Abstract: Chronic kidney disease (CKD) represents a significant global health challenge, exhibiting a strong correlation with cardiovascular mortality. Conventional obesity metrics, including body mass index (BMI) and waist circumference (WC), offer an incomplete assessment of adiposity-related risk in CKD patients. The weight-adjusted waist index (WWI) is a relatively new anthropometric indicator, and its prognostic significance in CKD remains to be fully elucidated. This study aims to examine the relationship between the weight-adjusted waist index (WWI) and mortality outcomes, specifically cardiovascular disease (CVD)-specific and all-cause mortality, in individuals with CKD. This retrospective cohort study leveraged data from the National Health and Nutrition Examination Survey (NHANES 2005–2018) and the National Death Index (NDI). Over a median follow-up period of 79 months involving 5,381 participants, higher WWI quartiles demonstrated associations with incrementally increased risks of CVD (highest vs. lowest quartile OR: 1.81, 95% CI: 1.39–2.34) and mortality (CVD HR: 1.73, 95% CI: 1.15–2.60; all-cause HR: 1.45, 95% CI: 1.22–).