Prompt Description

Graphical Abstract: Circadian Syndrome (CircS) and Stroke Risk Background: This study investigated the association between a newly proposed Circadian Syndrome (CircS)—a cluster of cardiometabolic risk factors linked to circadian rhythm disruption—and the incidence of stroke. Methods: A large-scale cohort study was conducted involving 8,032 participants from a baseline population of 17,708 individuals. The presence of CircS and its individual components were assessed at baseline, and participants were followed for incident stroke. Key Findings: Baseline Comparison: At baseline, participants who developed a stroke (n=746) had a significantly higher prevalence of CircS (54.83%) compared to those who did not (37.32%, p<0.001). CircS as a Risk Factor: The presence of CircS was a significant independent predictor of stroke. After adjusting for age, BMI, education, lifestyle factors, and medications, CircS was associated with a 41% increased risk of stroke (HR: 1.41, 95% CI: 1.20-1.6).