![You are a world-class visual explanation expert. Please convert this concept into an infographic: [1. Platelets were incubated with acridine yellow (Af) to obtain Af-loaded platelets (Af@Plt), and then incubated with fluorescein diacetate (FDA) to obtain platelets co-loaded with acridine yellow and fluorescein ((Af+Flu)@Plt). 2. (Af+Flu)@Plt were injected into blood vessels and distributed to tumor vessels via blood flow. 3. Under ultrasound stimulation, (Af+Flu)@Plt in tumor vessels were activated and released Af and Flu into the tumor tissue. The released Af and Flu were taken up by tumor cells and tumor-associated macrophages (TAMs). 4. Under ultrasound stimulation, tumor cells and TAMs that had taken up Af and Flu generated a large amount of reactive oxygen species (ROS) inside, resulting in oxidative damage and death, and released Af to surrounding cells. 5. In tumor tissue, low concentrations of Af stimulated M2-type TAMs to exhibit an M1-like anti-tumor phenotype, thereby killing tumor cells. At the same time, Af induced tumor cells to release the 'find me' signal ATP and express the 'eat me' signal CRT on the cell surface, thereby promoting the killing of tumor cells by M1-like phenotype TAMs. In tumor tissue, high concentrations of Af disabled M2-type TAMs, preventing M2-type TAMs from interacting with tumor cells, thereby canceling various pro-tumor functions of M2-type TAMs.]](/_next/image?url=https%3A%2F%2Fpub-8c0ddfa5c0454d40822bc9944fe6f303.r2.dev%2Fai-drawings%2F3o7tkY1PoOleTgaRBMncH8gOaVkX0IO8%2F3ce60887-256f-4fc5-a816-60f7154a1007%2F68e5cec3-79bc-4cbd-8cf9-a9e2df1d9aa2.png&w=3840&q=75)
Prompt Description
You are a world-class visual explanation expert. Please convert this concept into an infographic: [1. Platelets were incubated with acridine yellow (Af) to obtain Af-loaded platelets (Af@Plt), and then incubated with fluorescein diacetate (FDA) to obtain platelets co-loaded with acridine yellow and fluorescein ((Af+Flu)@Plt). 2. (Af+Flu)@Plt were injected into blood vessels and distributed to tumor vessels via blood flow. 3. Under ultrasound stimulation, (Af+Flu)@Plt in tumor vessels were activated and released Af and Flu into the tumor tissue. The released Af and Flu were taken up by tumor cells and tumor-associated macrophages (TAMs). 4. Under ultrasound stimulation, tumor cells and TAMs that had taken up Af and Flu generated a large amount of reactive oxygen species (ROS) inside, resulting in oxidative damage and death, and released Af to surrounding cells. 5. In tumor tissue, low concentrations of Af stimulated M2-type TAMs to exhibit an M1-like anti-tumor phenotype, thereby killing tumor cells. At the same time, Af induced tumor cells to release the 'find me' signal ATP and express the 'eat me' signal CRT on the cell surface, thereby promoting the killing of tumor cells by M1-like phenotype TAMs. In tumor tissue, high concentrations of Af disabled M2-type TAMs, preventing M2-type TAMs from interacting with tumor cells, thereby canceling various pro-tumor functions of M2-type TAMs.]
