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SARS-CoV, MERS-CoV, SARS-CoV-2, Dengue, Zika, bats, camel... | SciDraw Gallery

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SARS-CoV, MERS-CoV, SARS-CoV-2, Dengue, Zika, bats, camels, pigs, civets, monkeys, Aedes mosquitoes, humans

Biomedical

Prompt Description

SARS-CoV, MERS-CoV, SARS-CoV-2, Dengue, Zika, bats, camels, pigs, civets, monkeys, Aedes mosquitoes, humans

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Schematic Title: Schematic Diagram of Microneedle Patch Preparation Process

Overall Style and Layout:

Style: Simple, modern, with technological line illustrations or flat vector graphics. Use a refreshing color scheme, mainly blue, gray, and white, with key parts highlighted in orange or green.

Layout: A horizontal flowchart from left to right, including 4 core steps. Each step is clearly marked with a numbered module (Step 1-4).

Detailed Description of Steps:

Step 1: Mold Casting

Scene: On the left is a transparent/translucent polymer microneedle mold (such as a PDMS mold), with a regularly arranged array of inverted pyramid or conical pits visible on its surface.

Action: A pipette or dropper is dropping a drop of viscous, translucent mixed solution onto the surface of the mold. The solution can be symbolically dotted with tiny nanoparticles (NPs) to represent DNase-PDA@C-176 NPs.

Label: Label the solution as "HA and DNase-PDA@C-176 NPs mixed solution". Label the mold as "Microneedle Mold".

Step 2: Vacuum Filling

Scene: The mold is placed in a transparent vacuum chamber.

State: The solution on the surface of the mold has spread and covered the entire mold area. A vacuum pump icon (or a simple downward arrow indicating air extraction) is connected above the vacuum chamber.

Key Visual: In the pits of the mold, use an enlarged partial cross-sectional view to show that the solution is being drawn down under the action of vacuum negative pressure, completely filling every tiny corner of the pit and expelling all air bubbles. A few small upward air bubble arrows can be used to indicate the dynamic process of exhaust.

Label: "Vacuum Filling" or "Vacuum Degassing".

Step 3: Drying and Curing

Scene: The mold is transferred to a dry environment, such as being placed under a gentle warm air flow (indicated by curved arrows) or placed in a "drying oven" icon.

State: The moisture in the solution in the mold evaporates, the volume shrinks, and finally solid needles are formed in the mold pits. A partial cross-sectional view can be used again to compare: from pits filled with liquid to solid needles.

Label: "Drying/Curing".

Step 4: Demolding and Finished Product

Action: A hand or a robotic arm is carefully peeling/removing a formed microneedle patch substrate (a transparent polymer backing) from below.

Finished Product Display: The peeled patch is displayed completely. Hundreds of tiny conical needle tips stand neatly on the patch substrate, forming a perfect array.

Multi-angle Display (Optional):

Main View: Complete patch.

Side View/Magnified View: Shows the sharp needle tip and complete shape of a single microneedle, with dimensions labeled as "Height: 1000 μm, Base Width: 600 μm".

Top View (Illustration): Shows the regular arrangement of microneedles, such as a "10x10 array" or similar.

Final Label: Label the finished product as "DNase-PDA"

Schematic Title: Schematic Diagram of Microneedle Patch Prep...

A pipette with a tip attached.

A pipette with a tip attached....

Six jars of water kefir, two units of honey, two units of molasses, and two units of brown sugar were prepared and covered with cheesecloth.

Six jars of water kefir, two units of honey, two units of mo...

Methods: Adult male Wistar rats were subjected to diffuse severe traumatic brain injury (TBI) using the Marmarou weight-drop model under anesthesia. Thirty minutes post-injury, pinocembrin (Pino) was administered intraperitoneally at doses of 25, 50, and 100 mg/kg. Neurological function was assessed using the Veterinary Coma Scale, beam walk, and beam balance tests at baseline, immediately after recovery from anesthesia, and at 24, 48, and 72 hours post-trauma. Cerebrospinal fluid (CSF) samples were collected for ELISA analysis of matrix metalloproteinase-9 (MMP-9), and brain tissues were fixed in 10% formalin for histological evaluation using hematoxylin and eosin staining.
Results: Severe TBI induced significant neurological deficits, increased cerebral edema, disruption of blood-brain barrier (BBB) integrity, and impaired balance and motor performance. Treatment with pinocembrin at 25 and 50 mg/kg significantly attenuated these pathological changes compared with controls (p < 0.001). These doses also reduced cerebrospinal fluid MMP-9 levels, which were markedly elevated following TBI.

Methods: Adult male Wistar rats were subjected to diffuse se...