Prompt Description

A schematic diagram illustrating the molecular mechanism by which the extracellular matrix protein Fibronectin (FN) promotes viral infection. FN interacts with the grass carp reovirus (GCRV) outer capsid protein VP7 and the host membrane receptor protein ITGB1, activating the NF-κB signaling pathway and cytoskeletal protein rearrangement, inducing the formation of "pseudopodia" on the cell surface, and promoting viral infection. The pro-viral mechanism of FN is evolutionarily conserved and also applies to other aquatic viruses such as SVCV and KHV, as well as the mammalian virus VSV.