Prompt Description

Title: Delayed Immunomodulation Reverses Functional Connectivity and Motor Deficits in Adulthood After Neonatal Hypoxia-Ischemia (HI) Authors: Sanjana Mandhan, Eric Chin, Anushka Acharya, Riddhi Patel, Fabiola Beatriz Santiago Maldonado, Diana Ortega, Hawley Helmbrecht, Shenandoah Robinson, Lauren Jantzie. Background: Neonatal hypoxic-ischemic encephalopathy (HIE) occurs when the newborn brain is deprived of oxygen and blood flow around the time of birth. It remains a major cause of lifelong neurological and developmental disability in term infants. The resulting inflammation, oxidative stress, and cell death disrupt normal brain development, leading to long-term problems in movement, learning, and cognition. Current treatments such as therapeutic hypothermia provide only limited protection and do not completely prevent these functional disabilities. To this end, we repurposed an immunomodulatory cocktail containing melatonin to test the hypothesis that disrupted functional neural