Prompt Description

We hypothesize that infiltrating sensory nerves in cervical cancer promote tumor EMT by releasing SP, which binds to the TACR1 receptor on tumor cells and phosphorylates Src protein kinase. Simultaneously, this process reduces CCL7 secretion while promoting IL-33 secretion, establishing an immunosuppressive tumor microenvironment, leading to insensitivity to neoadjuvant chemotherapy combined with immunotherapy.