Prompt Description

Scene Description: Please generate a mechanistic diagram for a biomedical master's thesis, with a professional, concise, and logically clear style. Adopt a left-to-right or center-out layout, distinguishing between "Diabetic Injury" and "Therapeutic Intervention" sections. Visual Elements and Layout Suggestions: Left Side (Injury Side): Background labeled "High Glucose (HG) Microenvironment," with a dark tone (e.g., light gray). Draw a simplified diagram of a vascular endothelial cell. Above or inside the cell, use "↓" symbols and dashed arrows to indicate two inhibited pathways: Pathway 1 (Top): Label "Hippo Pathway Inhibition," key molecular changes: P-YAP ↓ → YAP nuclear translocation ↑ → leading to "Inflammatory Response ↑" (represented by an explosion icon, labeled IL-1β, IL-6, TNF-α ↑). Pathway 2 (Bottom): Label "Wnt/β-catenin Pathway Inhibition," key molecular changes: β-catenin ↓ → CyclinD1 ↓. Below the cell, use downward arrows and crosses to indicate cellular functional consequences: Cell proliferation ↓, Cell migration ↓, VEGF/PCNA ↓. Center (Intervention and Turning Point): Place a prominent bottle or container icon in the center, labeled "Lucilia sericata Larval Extract MWE-A," and use a thick green solid arrow pointing to the cell on the right, indicating therapeutic intervention. Right Side (Therapeutic Recovery Side): Background labeled "MWE-A Treatment," with a bright tone (e.g., light blue or green). Draw a simplified diagram of a healthy, active endothelial cell. Inside the cell, use "↑" symbols and solid arrows to indicate two activated pathways: Pathway 1 (Top): Label "Hippo Pathway Activation," key molecular changes: P-YAP ↑ → YAP nuclear translocation ↓ → leading to "Inflammatory Response ↓" (inflammation icon reduced or disappeared). Pathway 2 (Bottom): Label "Wnt/β-catenin Pathway Activation," key molecular changes: β-catenin ↑ → CyclinD1 ↑. Below the cell, use upward arrows to indicate functional improvements: Cell proliferation ↑, Cell migration ↑, VEGF/PCNA ↑. On the right side of the cell, draw a simplified diagram of the skin wound healing process: A wound that is closing. Draw newly formed capillaries inside the wound (labeled CD31↑). Use icons to represent increased collagen fiber and epithelial layer coverage. Bottom Summary Box: At the bottom of the diagram, use boxed text to summarize the core conclusion: "MWE-A improves endothelial function and accelerates diabetic wound healing by synergistically activating the Hippo pathway (increasing P-YAP) to inhibit inflammation and activating the Wnt/β-catenin pathway (stabilizing β-catenin) to promote proliferation." Style Requirements: Flat or minimalist line style, professional color scheme (e.g., use blue/green to represent activation/benefit, red/gray to represent inhibition/damage). All molecule names, pathway names, arrows