14:[["$","title","0",{"children":"flowchart TD\n A[起始：营养过剩/肥胖] --> B[脂肪组织病理性扩张
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细胞肥大、缺氧、应激]\n \n B --> C[局部炎症与功能障碍
巨噬细胞浸润 M1极化
脂联素↓ 促炎因子↑]\n \n C --> D{系统性信号输出}\n \n D --> E[异常分泌谱
（脂肪因子、细胞因子）]\n D --> F[脂毒性物质溢出
（FFA、神经酰胺）]\n D --> G[外泌体介导的通讯
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糖异生↑、脂质沉积]\n H2[骨骼肌：胰岛素抵抗、
葡萄糖摄取↓]\n H3[胰腺β细胞：功能失调、
炎症、凋亡]\n H4[下丘脑：中枢抵抗、
食欲调控失衡]\n end\n \n H --> I[全身性胰岛素抵抗
+ β细胞功能衰竭]\n I --> J[最终结局：2型糖尿病 T2DM]\n \n K[外部调节因素
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细胞肥大、缺氧、应激]\n \n B --> C[局部炎症与功能障碍
巨噬细胞浸润 M1极化
脂联素↓ 促炎因子↑]\n \n C --> D{系统性信号输出}\n \n D --> E[异常分泌谱
（脂肪因子、细胞因子）]\n D --> F[脂毒性物质溢出
（FFA、神经酰胺）]\n D --> G[外泌体介导的通讯
（携带特定miRNA等）]\n \n E & F & G --> H[靶器官损伤与功能紊乱]\n \n subgraph H [靶器官损伤与功能紊乱]\n H1[肝脏：胰岛素抵抗、
糖异生↑、脂质沉积]\n H2[骨骼肌：胰岛素抵抗、
葡萄糖摄取↓]\n H3[胰腺β细胞：功能失调、
炎症、凋亡]\n H4[下丘脑：中枢抵抗、
食欲调控失衡]\n end\n \n H --> I[全身性胰岛素抵抗
+ β细胞功能衰竭]\n I --> J[最终结局：2型糖尿病 T2DM]\n \n K[外部调节因素
（肠道菌群失调/益生干预）] -.->|双向影响| B\n K -.->|双向影响| C\n \n L[新兴治疗靶点与策略] -.->|干预| C\n L -.->|干预| E\n L -.->|干预| F\n L -.->|干预| G"}],"$L23","$L24","$L25","$L26","$L27","$L28","$L29","$L2a","$L2b","$L2c","$L2d","$L2e","$L2f","$L30"]