
帮我生成图片:Abstract Chronic kidney disease (CKD) is a major global health burden strongly linked to cardiovascular mortality. Traditional obesity indices such as body mass index (BMI) and waist circumference (WC) incompletely capture adiposity risk in CKD. The weight-adjusted waist index (WWI) is an emerging anthropometric measure, but its prognostic value in CKD has not been fully established. This study investigates the association between the weight-adjusted waist index (WWI) and mortality outcomes—CVD-specific and all-cause—among individuals with CKD. This retrospective cohort study utilized data from the National Health and Nutrition Examination Survey (NHANES 2005–2018) and the National Death Index (NDI). During a median follow-up of 79 months, among 5,381 participants, higher WWI quartiles were associated with progressively elevated risks of CVD (highest vs. lowest quartile OR: 1.81, 95% CI: 1.39–2.34) and mortality (CVD HR: 1.73, 95% CI: 1.15–2.60; all-cause HR: 1.45, 95% CI: 1.22–1.72). Subgroup and sensitivity analyses confirmed the robustness of these findings. Mediation analysis indicated that both the neutrophil-to-lymphocyte ratio (NLR) and systemic inflammation response index (SIRI) significantly mediated the associations between WWI and all-cause mortality, as well as between WWI and CVD-specific mortality. In the fully adjusted Model 2, ROC curve analysis revealed area under the curve (AUC) values for WWI with CVD mortality and all-cause mortality of 0.793 and 0.763, respectively. This study provides the first evidence that WWI is significantly associated with CVD risk and mortality outcomes, including both CVD-specific and all-cause mortality, in U.S. CKD populations. Mediation analysis suggested that NLR and SIRI partially mediated the relationship between WWI and these mortality outcomes Make high quality graphical abstract

Diese Studie verwendete Daten aus der China Health and Retir...